Transcriptomics: Open Access
Open Access

Abstract

Unraveling the Progression of Ischemic Core Genome-Wide by Bioinformatics Analysis of Permanent Middle Cerebral Artery Occlusion (PMCAO) Mouse Model Brain Regions Genes

Motohide Hori, Tomoya Nakamachi, Junko Shibato, Randeep Rakwal, Seiji Shioda and Satoshi Numazawa

The neuropeptide, pituitary adenylate-cyclase activating polypeptide (PACAP) , is the major focus of research as a neuroprotective factor in the group of Prof. S. Shioda. A major emphasis of the research is on the neuroprotective effects of PACAP38 on the brain, particularly in brain ischemia . Therein, a permanent middle cerebral artery occlusion (hereafter referred to as PMCAO) mouse model has been established and used for unraveling of the genome-wide gene expression profiles by high-throughput omics approach, namely DNA microarray technology.