Journal of Clinical and Experimental Ophthalmology

Journal of Clinical and Experimental Ophthalmology
Open Access

ISSN: 2155-9570

+44 1223 790975


Transient Choroidal Thinning after Intravitreal Bevacizumab Injection for Myopic Choroidal Neovascularization

Kaori Sayanagi, Yukari Jo and Yasushi Ikuno

Purpose: To evaluate the choroidal thickness changes in the eyes with myopic choroidal neovascularization (mCNV) after intravitreal injection of bevacizumab (IVB).
Ten highly myopic eyes with mCNV treated with IVB were included. All patients underwent a single, horizontal B-scan image centered on the fovea, before, and 1 month and 3 month after IVB using Heidelberg optical coherence tomography (OCT). Choroidal thickness (CT) defined as the distance from the retinal pigment epithelium to the chorio-scleral interface in OCT image at the fovea, 2mm nasally and 2mm temporally was measured.
Foveal mean CT was 52.8 microns before IVB, and it significantly decreased to 37.5 microns 1 month after (P<0.05). Similarly, the 2mm temporal mean CT was 80.5 microns before IVB, and it significantly decreased to 69.5 microns 1 month after (P<0.05). On 3 months after IVB, mean CT at the fovea improved to 48.9 microns (P=0.67); however, the mean temporal CT remained thin as 67.0 microns (P=0.07 vs. baseline). The mean nasal CT remained at the similar throughout the follow-up (P=0.90 and 0.56) The change in CT on 1 month after IVB was significantly correlated with age and preoperative CT (P=0.01 and 0.04, respectively).
Conclusions: Subfoveal and temporal choroidal thinning is transiently observed. IVB may affect the choroidal circulation in such myopic eyes as with thin choroid.