Transcriptomics: Open Access
Open Access

Abstract

Transcriptional Activity of Vitamin D Receptor Gene (VDR) and Transforming Growth Factor Beta (TGF-Β) Signaling Differentiate Juvenile and Adolescent Idiopathic Scoliosis.

Roman Nowak

Idiopathic scoliosis (IS) is the most common spinal deformity in humans. The exact causes of this condition are unknown but the genetic background seems undisputable. Genetic background doesn’t preclude that IS could be a systemic molecular disorder reflected by local processes affecting musculoskeletal structures of the spine during periods of intensive growth. The age of scoliosis onset is one of the most important factors determining the natural history and the risk of progression. Most of the idiopathic curves are diagnosed in juvenile (Juvenile Idiopathic Scoliosis -JIS) or adolescent period (Adolescent Idiopathic Scoliosis - AIS).