Journal of Clinical Chemistry and Laboratory Medicine
Open Access

Abstract

Synthesis and Pharmacological Evaluation of 1-Oxo-2-(3-Piperidyl)-1, 2, 3, 4-Tetrahydroisoquinolines as a New Class of Specific Bradycardic AgentsPossessing I (F) Channel Inhibitory Activity: N-Methyl-D-Aspartate Receptor Modulators that Potentiates Glun2b-Containing N-Methyl-D-Aspartate Receptors

Suman Thummanagoti1, Chih-Hau Chen1, Zhan-Hui Xu1, Chung-Ming Sun1*

The test strategy is to use soluble polymer carrier polyethylene glycol (Poly ethylene glycol will be referred to as PEG for short) quantity 6000 or leave liquid carrier (Ionic-liquid support), coupled with the protected compound 80, for use with analogy Under acidic conditions, enter the row Pictet-Spengler reaction to obtain the desired heterocyclic compound tetrahydroiso-quinolines, profit use different cyanate (ioscyanate) and different cyanate (iosthiocyanate) under alkaline conditions to enter row cyclization cut to remove the carrier to obtain the second heterocycle , Such as Scheme 2-1. Several novel multicomponent assembly processes have been developed for the rapid and efficient assembly of various heterocyclic scaffolds bearing a tetrahydroisoquinoline core, each of which allows for facile derivatization to access a diverse array of compounds. This work led to the serendipitous discovery of a new method for the synthesis of a fused ring system.

Published Date: 2021-11-05;