During inhalation oxygen molecules are drawn towards type I cells. The partial pressure difference and solubility factor act as a Drive for this movement of oxygen molecules. It is well known that the pulmonary surfactant plays an important role in gas exchange. The surfactant is thin mono-layer. The top surface of surfactant with SP-B and C proteins faces alveolar air and is hydrophobic in nature and acts as a surface tension reducer, whereas lower surface with SP-A and D proteins is hydrophilic and is adsorbed on mucosal layer. This lower surface of surfactant acts as an anti-invader, pathogen barrier. However there is a small missing link in explaining its exact mechanism or role in justifying these properties during normal conditions and during ‘viral ligand’ attack.
Similarly a unique physical property of SP-C component is listed in research papers; however its application is not researched anywhere. SP-C has a dielectric constant of 2 to 3 and plays a very critical role in drastically reducing progression of any respiratory viral disease including SARS-CoV-2. This hypothesis targets to explain both micro mechanisms with the help of basic laws of physics, and fluid mechanics. The figures/sketches, drawn also depict the physics involved and not much of a physiology or genetic codes etc. Two examples, in the industry, are briefly listed in the last paragraphs to draw some parallel with above mechanisms.
Vaccination is a proven method for containment of respiratory viral disease, if not its cure. But if focus is also given on health of pulmonary surfactant with respect to pathogenesis of any respiratory viral disease, probable loss of lot many lives can be avoided and vaccine development and vaccination management related issues can be less panicky.
Published Date: 2021-10-29; Received Date: 2021-10-08