Journal of Clinical Trials
Open Access

Abstract

Prevalence of Transfusion-Transmissible Infections among Voluntary Blood Donors in Tertiary Health-Care Facility in Islamabad, Pakistan

Fariha M Siddiqui, Niaz Ahmed, Olasunkanmi Oluwatayo, Sadia Jabeen, Syed Mehmood Qadir, Sajjad A Khan, Sajjad Hussain, Roohullah and Abdul Sattar

Objective: Transfusion-transmissible infection in asymptomatic donors is the major risk factors for transmission of infectious agents through blood transfusion. The objective of this study is to determine the seroprevalence, risk factors of Transfusion Transmissible Infections (TTIs) in blood donors in Islamabad, using a tertiary health-care centre as a case study.

Study design: A total number of 847 blood donors, at health care facility, were recruited into the study. This study was conducted from 1st November 2016 to 31st October 2017. World Health Organization (WHO) Protocols and Requirement for blood donation were used as Selection Criteria for the blood donors.

Methods: Immunochromatographic assay kit and chemiluminescence immunoassay were used to detect the TTI in the serum sample of the donors. The kit has been designed for qualitative determination of TTI in human serum. The immunoassay was performed in fully automated chemiluminescence immunoassay (CLIA) analyzer MAGLUMI (Maglumi 1000).

Results: The result shows that 32 (3.72%) of the blood donors had TTIs. The prevalence of Hepatitis B, Hepatitis C, Malaria, Syphilis and Human immunodeficiency viruses (HIV), was found to be 11 (1.29%), 15 (1.77%), 01 (0.11%), 03 (0.35%) and 02 (0.0.23%) respectively.

Conclusion: This study shows that TTIs appears to be lower among voluntary blood donors. However, a more expanded study should be extended to the general population. This is important; it will be helpful in planning public health interventions against TTIs.