Cell & Developmental Biology
Open Access
ISSN: 2168-9296
ISSN: 2168-9296
Objective: To comprehensively review the current evidence on the mechanisms of action, efficacy, delivery approaches and combination therapy prospects of sulforaphane for breast cancer management. Background: Breast Cancer (BC) is a leading cause of cancer mortality worldwide. It needs improved prevention and treatment strategies because of the metastasis and drug resistant problems. Sulforaphane is a natural compound derived from cruciferous vegetables that has shown potent anticancer activity.
Methods: This narrative review was done by a systematic search across PubMed, Google Scholar, Scopus and Clinical Trials Government (CTG) from 2004 to 2023. Included articles were 31.
Results: Numerous studies demonstrated sulforaphane's antiproliferative and pro-apoptotic effects against breast cancer cells and cancer stem cells through epigenetic regulation, signaling pathway modulation and other mechanisms. Preclinical studies showed sulforaphane inhibited tumor growth and metastasis. Combining sulforaphane with chemotherapy enhanced efficacy and reduced toxicity. Nanoparticle formulations improved sulforaphane bioavailability and targeted delivery.
Conclusion: Sulforaphane exhibits promising therapeutic potential against breast cancer through multiple molecular mechanisms. Evidence supports its use as an adjunct to conventional treatments and warrants further exploration in clinical trials. Optimized delivery approaches may aid translation of these findings into effective breast cancer management strategies.
Published Date: 2026-02-17; Received Date: 2024-11-13