Climate Change is a hot issue in the world. Effect of climate change on yield of two varieties of boro rice has been assessed using the CERES Rice model of the DSSAT modeling system. The yield of BR3 and BR14 boro varieties for the years 2008, 2030, 2050 and 2070 have been simulated for 12 locations (districts) of Bangladesh, which were selected from among the major rice growing areas in different regions of Bangladesh. The CERES-Rice model uses a detailed set of crop specific genetic coefficients for predicting yield (BR3 and BR14) because “genetic coefficients” for these varieties are available in the DSSAT modeling system. Available data on soil and hydrologic characteristics of these locations, and typical crop management practice for boro rice were used in the simulations. The weather data required for the model (daily maximum and minimum temperatures, daily solar radiation and daily precipitation) were generated for the selected years and for the selected locations using the regional climate model PRECIS. The model predicted significant reduction in yield of both varieties of boro rice due to climate change; yield reductions of over 20% and 50% have been predicted for both rice varieties for the years 2050 and 2070, respectively. Increases in daily maximum and minimum temperatures have been found to be primarily responsible for reduction in yield. Increases in incoming solar radiation and atmospheric carbon-di-oxide concentration increases rice yield to some extent, but their effect is not significant compared to the negative effects of temperature. Variations in rainfall pattern over the growing period have also been found to affect rice yield. Increasing temperatures and solar radiation have been found to reduce the duration of physiological maturity of the rice varieties. Model results also suggest that in addition to reducing yield, climate change may also make rice yield more vulnerable to transplanting date, predicting significant reduction in yield as transplanting date is delayed, especially beyond 15 January. DSSAT modeling system could be a useful for assessing possible impacts of climate change and management practices on different varieties rice and other crops.