Journal of Clinical and Cellular Immunology
Open Access

Abstract

Exercise-Mediated Immune Protection in Chronic Kidney Disease Decreases Infection and Severe Evolution of COVID-19

Josiano Guilherme Puhle, Vanessa da Silva Corralo, Adinei Abadio Soares, Joao Vitor Kroth, Mariana Munhoz Gallina, Matheus Goncalves Cavasin, Vinicius Ansolin, Danieli de Cristo, Angela Makeli Kososki Dalagnol, Debora Tavares de Resende e Silva*, Gabriela Vidotto Cavallieri and Renata Calciolari Rossi

It is constantly sought to understand the different mechanisms of action of the immune system to establish potential efficient therapeutic targets for different clinical situations. Thus, the present study aims to expand the knowledge about the protective effect of physical exercise on the immune system of patients with chronic renal failure, associating it with the incidence of infection by COVID-19. The present study was based on a narrative systematic review of the literature and understands, elucidate, and discuss the subject. The main result found was that regular, moderate-intensity exercise modulates immunological parameters in CKD patients, evidenced by decreased inflammatory factors such as Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-18 (IL-18) and Tumor Necrosis Factor-α (TNFα), and increased Interleukin-10 (IL-10) and Interleukin-4 (IL-4). Decreases in C-reactive protein and intercellular Adhesion Molecule-1 (ICAM-1) were also seen, associated with increased activity of leukocytes, Natural Killer (NK) cells, and CD8⁺ T cells. Based on this, moderate and continuous exercise is a protective therapy for kidney patients, causing a decrease in the risk of morbidity and mortality caused by COVID-19 infection.

Published Date: 2023-07-31; Received Date: 2023-06-30