Transcriptomics: Open Access
Open Access

Abstract

Etiopathogenesis of Gastric Cancer

Vedat Goral

Gastric cancer is a multifactorial and complex malignant disease seen commonly worldwide. It is one of the few malignant condi­tions in which the etiology involves infectious agents (Helicobacter pylori), but there are many other risk factors incuding high salt intake. Its pathogenesis generally involves interactions between environmental factors and genetic disposition. It is currently on­sidered that stem cells may play a central role in gastric cancer development. According to gene expression studies, there are two molecular types of gastric cancers . 1) Diffuse type (undifferenti­ated) gastric cancer 2) Intestinal type (well differentiated) gastric cancer. The major cause in diffuse carcinoma is genetic events and the most important of these is loss of E-cadherin expression. E-cad­herin plays the role of key cellular protein in ensuring intracellular links and epithelial tissue organization. Intestinal type gastric can­cer is generally associated with H. pylori and its prognosis is better compared to diffuse type gastric cancer. Diffuse gastric cancer; are associated with more.

Also, gastric cancer is a multistep event involving multiple genet­ic and molecular alternations and changes in cancer stem cells. Progression from preneoplastic lesions to cancer is associated with CSC (cancer stem cell) induction, increased cell proliferation and apoptosis

Published Date: 2020-12-26; Received Date: 2020-10-09