Translational Medicine
Open Access

Abstract

Cytotoxic Activity of Extracts/Fractions of Various Parts of Pistacia Integerrima Stewart

Ghias Uddin, Abdur Rauf, Bina Shaheen Siddiqui and Haroon Khan

The aim of present study was to scrutinize cytotoxic activity of extracts/fractions of various parts of Pistacia integerrima Stewart in an established in-vitro brine shrimp cytotoxic assay. The extracts/fractions of different parts of the plant demonstrated profound cytotoxic effect against Artemia salina (Leach) shrimp larvae. Of the various parts of plant tested, galls accumulated most cytotoxic agents. Among the tested extracts/fractions, hexane was least cytotoxic and therefore indicated more polar nature of cytotoxic constituents. In conclusions, extracts/fractions of various parts of P. integerrima exhibited marked cytotoxic profile of more polar nature.