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Transcriptomics: Open Access

Transcriptomics: Open Access
Open Access

ISSN: 2329-8936

+44 1223 790975

Abstract

Advantages and Limitations of utilizing Clostridium species as Probiotics-ASytematic Review

Kulvinder Kochar Kaur

Having reviewed the role of Gut microbiota(GM) earlier , in Gas­trointestinal Tract(GIT)homeostasis through the multiple bacte­ria on the role of gut microbiota(GM) in obesity as well as met­abolic disorder liketype 2 diabetes mellitus( T2DM), non alcoholic fatty liver disease(NAFLD),role of probiotics as well as prebiot­ics in preventing obesity ,NAFLD,besides engineering probiotics for tackling lots of diseases besides in its role in neuropsychiatric disease(NPD) prevention along with maintaining intestinal homeostasis,here we have tried to go further and study the role of specific commensal bacteria like the Clostridia species(spp.). Clos­tridia spp.,representing the major commensal bacilli in the intes­tines ,influence plenty of salutary actions on this homeostasis of the intestine.Thesespp. have been documented to ameliorate inflammation as well as allergic diseases successfully in view of their specific biological actions .The cellular parts as well as me­tabolites they form like butyrate,secondary bile acids as well as in­dole propionic acids exert a probiotic action mainly via providing energy to the intestinal epithelial cells ,by which the give strength to the intestinal barrier along with crosstalk with the immune sys­tem(reviewed by us in detail earlier ).Hence in turn ,the diet as well as state of the physiological body shape a specific pattern of Clostridia spp., in gut.In view of their biological actions Clostrid­ia spp., have massive potential in the form of probiotics .Yet safety evaluation has not been conducted till now,hence some nonneg­ligible chances of complication following l their use .Hence here we have tried to review both advantages ,in addition to difficulties in using them as probiotics to form Clostridia spp., as innovative probiotics for animal health as well as animal generation

Published Date: 2020-12-26; Received Date: 2020-10-26

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