Gynecology & Obstetrics
Open Access
ISSN: 2161-0932
ISSN: 2161-0932
Ibrahim A Albahlol
Department of Obstetrics and Gynecology, College of Medicine, Jouf University, KSA, Mansoura University, Egypt
Scientific Tracks Abstracts: Gynecol Obstet (Sunnyvale)
Background: Vitamin D deficiency during pregnancy has been associated with some adverse neonatal outcomes as well as an increased risk of late pregnancy complications that include preeclampsia, gestational diabetes mellitus and increased risk of preterm labor. Aim of work: To assess the correlation of pregnant serum Vit D level and different pregnancy complications regarding both mother and fetus and assess whether feto-maternal morbidities are associated with hypovitaminosis D or not. Patients and Methods: 322 participants who meted the inclusion citerias were classifi ed into 2 groups. The fi rst one was 110 pregnant with normal pregnancy regarding both fetal and maternal conditions were selected as control group. The second one was 212 pregnant suffering from pregnancy complications and were further subdivided into,58 cases with severe preeclampsia toxemia associated with intrauterine growth restriction, 82 case with GDM, 26 cases of abortion, 16 cases undisturbed ectopic pregnancy,14 case with premature rupture of membranes=PROM and 16 cases with inevitable preterm labor. Serum recovered from peripheral blood samples by centrifugation was aliquot stored till used at -80 oC. Specifi c quantitative ELISA immunoassay kits from Sunlong Biotech Co. Ltd. were used to measure 25-OH-VitD (in ng/mL) and 1,25-DiOH-VitD (in pg/mL) (cat# SL2762Hu and SL2845Hu, Hangzhou, Zhejiang, China). The direct DiOH-VitD/OH-VitD ratio was calculated for each patient. Results: 25 -OH -Vit D showed signifi cant differences only between control and GDM groups while there were no signifi cant differences among control and other groups. On the other hand,1,25-DiOH-VitD assay showed a very marked signifi cant reductions in comparing control versus all of 6 complicated groups. Very similar to 1,25-DiOH-VitD pattern, DiOHVitD/ OH-VitD ratio showed no signifi cant difference among the complicated groups. However, there were very marked signifi cant reductions comparing control vs. all of the 6 complicated groups Conclusions: There is a strong association of vit D status and certain pregnancy complications.1,25 Di-OH-Vit D assay seems to be more reliable than 25-OH-Vit D and could be used as a suitable biomarker in assessment of vit D status in pregnancy. Vit D supplementation during pregnancy may assist in reducing related complications. Key words: Vitamin D, Pregnancy Outcomes, Pregnancy Complications