GET THE APP

Ventricular ectopic burden as a predictor for survival in subject | 58173
Clinical & Experimental Cardiology

Clinical & Experimental Cardiology
Open Access

ISSN: 2155-9880

+44 1300 500008

Ventricular ectopic burden as a predictor for survival in subjects less than 65 years old


27th European Cardiology Conference

October 22-24, 2018 | Rome, Italy

Nikhil Sabharwal, Bobby John, Joshua Dunn and Venkat Vangaveti

James Cook University, Campus Name, Australia
The Townsville Hospital, Australia

Scientific Tracks Abstracts: J Clin Exp Cardiolog

Abstract :

Premature ventricular complexes (PVCs) are widely observed in the general population and are commonly asymptomatic. Several studies report a poor prognosis in conjunction with underlying structural heart disease (SHD), however, there is a lack of data implicating their clinical significance in the absence of SHD. A review of literature was conducted to determine the risk factors predisposing to PVCs. Variables explored in the studies included: age, presence or absence of SHD, PVC duration/morphology, morbidity and mortality. Data was collected according to the inclusion (age <65, 8 year follow-up, 24- hour ambulatory monitoring) and exclusion criteria (presence of SHD). Literature review revealed that the presence of PVCs indicate an increased risk of cardiovascular events (e.g. heart failure) in individuals aged >65 years, and is further amplified by factors such as PVC duration and morphology. A PVC burden of as low as 10% may significantly increase risk of PVC-induced cardiomyopathy. The limitations of current literature include: (1) analysis of a 2-minute rhythm strip; (2) short follow-up periods; and (3) failing to account for underlying SHD in <65 years old. The prognostic value of frequent PVCs in subjects <65 years old without underlying SHD is yet to be explored. A retrospective observational study is being conducted at Townsville Hospital to further investigate whether presence of PVCs, in health individuals <65 years old, should be treated as a modifiable risk factor. This will shed light upon whether more aggressive risk factor management is to be implemented and potential of interventions such as PVC ablation.

Top