Divya Dasagrandhi, R Arul Salomee Kamalabai and K S Jayachandran
Bharathidasan University, India
Posters-Accepted Abstracts: J Clin Exp Cardiolog
Myocardial Infarction (MI) is one major Cardiovascular Diseases (CVD), causes morbidity and mortality worldwide. Change in life style and dietary habits increases the occurrence of MI. Oxidative stress due to altered lipid metabolism is the key risk factor for MI. The present study is designed to understand the effect of saturated fatty acids on cardiac function and geometry. Twenty male guinea pigs of weight 450-550g were procured and divided into two groups and one of the groups was supplemented with high fat diet (HFD;10% lard) for a period of four months. After the induction, ECG and Echo-cardiogram were taken. Expression levels of inflammatory cytokines such as IL6, NF �?ºB and TNF�?± were analyzed in order to investigate the relationship between HFD and inflammation. No significant increase in body weight and heart rate were found. ECG showed a significant variation in P duration, QT and QTc interval but maintained sinus rhythm. Echocardiogram did not show any significant difference in left ventricular dimensions. But slight increase in posterior wall thickness and inter ventricular septum thickness was observed. Significant increase in the levels of IL6, NF�?ºB and TNF�?± were also observed. High fat diet with elevated amount of saturated fatty acids increases lipid profile and alters lipid metabolism which in turn leads to oxidative stress. It was clearly seen that oxidative stress has an effect on electrical conduction in heart. Thereby impairs the cardiac function. This was further confirmed by the elevated levels of inflammatory markers.