Organic Chemistry: Current Research
Open Access

Thermal, photooxidation and antifungal activity of monoterpene: Geranyl acetate

10^th European Organic Chemistry Congress

March 21-22, 2019 | Rome, Italy

Suzan A. Khayyat and Manal Y. Sameeh

University of Jeddah, Saudi Arabia Al Leith- Umm Al-Qura University, Saudi Arabia

Posters & Accepted Abstracts: Organic Chem Curr Res

Abstract :

Geranyl acetate (1) was epoxidated thermally and photochemically using (mcpba, H2O2) respectively to produce mixture of (E)-5-(3,3-dimethyloxiran-2-yl)-3-methylpent-2-enyl acetate (2) and 3-(2-(3, 3-dimethyloxiran-2- yl) ethyl) -3-methyloxiran-2-yl) methyl acetate (3) thermally. While produced epoxide (3) only photochemically. On the other hand, photooxygenation of (1) using tetraphenyl porphin (TPP) as photo sensitizer gave three hydroperoxide derivatives of Acitic acid 2,6-bis-hydroperoxy-7-methyl-3-methylene-oct-7-enyl-ester (4), Acitic acid 7-hydroperoxy-3,7-dimethyl-octa-2,5- dienyl ester (5) and Acitic acid 3-hydroperoxy-7-methyl-3,7-dimethyl-octa- 1,6-dienyl ester (6). Studies on the antifungal activity especially Microsporum gypsum and Trichophyton vercossum showed that geranyl acetate, its epoxides and hydroperoxides derivatives have good antifungal action.

Keywords: Antifungal activity, epoxidation, geranyl acetate, photooxidation, medicinal plants.

Biography :

Suzan A. Khayyat works as faculty in department of Chemistry, Faculty of Science at King Abdulaziz University, Jeddah in Saudi Arabia.