N Gorgaslidze, N Nizharadze, L Nadirashvili, G Erkomaishvili, Z Antelidze and M Getia
Tbilisi State Medical University, Georgia
Posters & Accepted Abstracts: J Chem Eng Process Technol
Enzymes as drugs are used for the treatment of many diseases. Nowadays, the number of enzyme containing preparations is not so great. This is due to several reasons: lack of resources, high price, immunogenic problems and low stability. The present work describes development of new drug forms - gels, containing bromelain and papain as well initial studies of standardization of the fruit bromelain and stem bromelain from the pineapple ( nanas comosus L.) and the comparative characterization of their physical-chemical properties. Particularly, influences of concentrations of cystein and casein on the speed of hydrolyze, dependence of casein lysis on concentration of bromelain, optimal parameters of pH and temperature were studied. The bases for the gels, which determine the optimal resorption and stability of the biological active compounds were selected (Table 1 and table 2).
N Gorgaslidze has completed her PhD from Saint-Petersburg State Chemical-Pharmaceutical Academy. She is the Director of TSMU I.Kutateladze Institute of Pharmacochemistry and Professor at the Department of Social and Clinical Pharmacy at Tbilisi State Medical University. She has published more than 80 papers in reputed journals.