The role of C-peptide in HIV associated pre-eclampsia | 41464
Gynecology & Obstetrics

Gynecology & Obstetrics
Open Access

ISSN: 2161-0932

The role of C-peptide in HIV associated pre-eclampsia

Joint Event on International Conference on Gynecology & Obstetrics Pathology & 2nd World Congress on Embryology & in Vitro Fertilization

March 30-31, 2018 | Orlando, USA

Thakoordeen S, Moodley J and Naicker T

University of KwaZulu-Natal, South Africa

Posters & Accepted Abstracts: Gynecol Obstet

Abstract :

Globally, pre-eclampsia is a major cause of maternal morbidity and mortality. In South Africa, HIV infection is an obstetric dilemma. During pregnancy, the placenta produces adipokines e.g., C-peptide, which is responsible for activating insulin. Obesity, immune dysregulation and inflammation contributes to an increased prevalence of insulin resistance. Due to the high obesity rate in sub-Saharan Africa and the metabolic adaptations of pre-eclampsia this study assessed the impact of C-peptide in HIV associated pre-eclampsia. Following institutional approval, participants (n=301) were recruited from a large regional hospital and divided into groups: non-pregnant (n=90), normotensive (n=121), early-onset (n=32; EOPE) and late-onset (n=58; LOPE) preeclampsia. All groups were stratified by HIV status. Maternal clinical demographics, indications and mode of delivery were recorded. Serum was used to quantify the C-peptide levels using Bioplex multiplex analysis (Bioplex Pro Human Diabetes 10-plex Panel). HIV status did not affect C-peptide levels. There was a significant difference in C-peptide between the non-pregnant versus normotensive pregnant (p<0.01) and the normotensive versus LOPE groups (p<0.01) albeit being elevated in both the pre-eclamptic groups. There was no significant effect of HIV status on baby weight. Baby weight was lower in the EOPE compared to the LOPE group (p<0.001). Body mass index was significantly elevated in normotensive HIV negative compared to normotensive HIV positive women (p<0.01). In conclusion, our study is the first to examine C-peptide dysregulation in the triad of HIV infection, pre-eclampsia and obesity. We demonstrate elevated c-peptide in pre-eclampsia whilst C-peptide was not affected by HIV status.