Gynecology & Obstetrics
Open Access
ISSN: 2161-0932
ISSN: 2161-0932
Mariam E. Mohammed
Gulf Medical University, UAE
Scientific Tracks Abstracts: Gynecol Obstet
Introduction: Holoprosencephaly (HPE) is a developmental defect that affects the brain structure due to failure or incomplete division of prosencephalon at 3rd week to 4th week of gestation into cerebral hemispheres. HPE can occur as an isolated malformation or often as a part of various syndromes. Objects: This case aims to highlight the crucial role of regular antenatal ultrasound scans in the early detection of fatal anomalies like alobar holoprosencephaly. Methods: A case of a 42-year-old pregnant woman (Gravida 3, Para 2) presented to the radiology department for an antenatal check-up at 16 weeks of gestation. Results & discussion: The ultrasound scan in our case revealed a large central monoventricle with a surrounding small rim of cerebral cortex, fused thalami and absence of midbrain structures like septum pellucidum, corpus callosum, and third ventricle which is suggestive of alobar holoprosencephaly. Ultrasound also detected other associated visceral anomalies like omphalocele, atrioventricular (AV) canal defect and left sided clubfoot. 3D ultrasound didnā??t reveal any midfacial abnormalities. Holoprosencephaly is a rare congenital malformation but one of the most common among central nervous system anomalies. Although the exact cause of holoprosencephaly remains unclear, it is suspected to result from a combination of genetic and environmental factors. HPE spectrum has four main types from the severe to the mild: alobar, semilobar, lobar HPE and syntelencephaly/midline interhemispheric variant. Conclusion: Alobar holoprosencephaly is the most severe form of holoprosencephaly, and regular antenatal ultrasound scans play a crucial role in the early detection of this fatal anomaly.
Mariam E. Mohammed is a fourth-year medical student at Gulf Medical University, committed to pursuing excel lence in clinical medicine and research. With a strong academic foundation and growing clinical experience, she is dedicated to expanding her knowledge, developing practical skills, and contributing to the advancement of health care. Mariam continues to explore her medical interests as she progresses toward a future career in the medical f ield.