Journal of Developing Drugs
Open Access

The influence of inhomogeneity of calcium alginate hydrogels on their controlled release properties

International Conference and Exhibition on Pharmaceutical Development and Technology

April 24-26, 2017 Dubai, UAE

Stojan Rendevski

HCT-Ras al Khaimah Men��?s Campus, UAE

Posters & Accepted Abstracts: J Develop Drugs Res

Abstract :

The controlled release properties of calcium alginate hydrogels are predetermined mainly by two factors: the monomer composition of the alginate (mannuronic-to-guluronic ratio) and the technology of gel preparation that lead to more or less homogenous hydrogels. The inhomogeneity of the calcium alginate hydrogels has been investigated in respect to the size and amount of calcium alginate micro-gel structure existing in the sodium alginate gelling solution. Dynamic light scattering measurements and scanning electron microscopy has been utilized for characterization of the hydrogels. The controlled release properties have been found dependent on the size and amount of calcium alginate micro-gels in respect to changed lag-time, intensity of the burst effect, release rate and release efficiency. The findings also suggest that the mixing technique plays an important factor in the preparation of homogen calcium alginate core hydrogels with or without a shell layer.

Biography :

Email: srendevski@hct.ac.ae