Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
ISSN: 2161-1017
Chijioke Orji
Imoniche Adeoye-Sunday, United Kingdom
Scientific Tracks Abstracts: Endocrinol Metab Syndr
Due to the obvious heterogeneity of osteosarcoma, many patients are not sensitive to neoadjuvant chemotherapy. In this study, the clinical characteristics and auxiliary examinations of patients with osteosarcoma were used to predict the effect of preoperative chemotherapy. So as to guide the clinical adjustment of the treatment plan to improve the prognosis of patients. In this study, 90 patients with pathologically confirmed osteosarcoma were included, and they were randomly divided into training cohort and validation cohort. A prediction model of preoperative chemotherapy efficacy for osteosarcoma was established by multivariate logistic regression analysis, and a nomogram was used as the visualization of the model. Decision curve analysis (DCA) was used to evaluate the net benefit of the nomogram in predicting the efficacy of neoadjuvant chemotherapy under different threshold probabilities. C-index and ROC curve were used to evaluate the accuracy of the nomogram. DCA showed that the model had good clinical application value. The AUC and C-index of the training cohort were 0.793 and 0.881 respectively. The AUC and C-index in the validation cohort were 0.791 and 0.818 respectively, which were close to the training cohort. In brief, based on the clinical characteristics of patients and auxiliary examinations, the model can better predict the efficacy of preoperative chemotherapy for osteosarcoma.
Chijioke K. Orji is a working in Imoniche Adeoye-Sunday in UK. He is interested in Osteoporotic research. He has at least 7 published papers. Through his work he hopes that his research activity would be valuable to help people all over the world.