The descending sympathetic pathways from dorsomedial hypothalamus | 16856
Endocrinology & Metabolic Syndrome

Endocrinology & Metabolic Syndrome
Open Access

ISSN: 2161-1017

+44 1478 350008

The descending sympathetic pathways from dorsomedial hypothalamus: Critical links to understand stress-related and obesity-related cardiovascular diseases

3rd International Conference on Endocrinology

November 02-04, 2015 Atlanta, USA

Marco Antonio Peliky Fontes

Universidade Federal de Minas Gerais, Brazil

Scientific Tracks Abstracts: Endocrinol Metab Syndr

Abstract :

Maintenance of homeostasis depends upon mechanisms controlling autonomic output. Sympathetic output depends on neuronal activity from different brain regions. Central requirement for changes in sympathetic output must be adjusted to the input signals from neural and humoral factors for an optimum cardiovascular performance. Consequently, abnormal inputs to one or more brain regions involved in the sympathetic control can lead to cardiovascular disease. Contributing factors may involve; abnormal feedforward and feedback mechanisms and altered humoral factors including angiotensinergic and leptinergic inputs. The dorsomedial hypothalamus is a key central region for the control of sympathetic outflow to the cardiovascular system. Recently, the descending sympathetic pathways from dorsomedial hypothalamus have been revealed. Reviewing the descending pathways from dorsomedial hypothalamus we discuss the interactions between mechanisms controlling the sympathetic output to the cardiovascular system and the possible implications in cardiovascular disease.

Biography :

Marco Antonio Peliky Fontes has completed his PhD from Federal University of Minas, Brazil and Post-doctoral studies from University of Sydney, Australia. He is an Associate Professor in the Department of Physiology and Biophysics at the UFMG. He has published more than 50 papers in reputed Physiology and Neuroscience journals. He is elected as a Member of the American Physiological Society and INCT Nanobiofar/Brazil. The central area of his research is cardiovascular neuroscience with focus in circuits involved in the cardiovascular response to emotional stress and the central contribution of peptides for cardiovascular control.