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The clinical use of human culture- expanded autologous bone marro | 21257
Journal of Cell Science & Therapy

Journal of Cell Science & Therapy
Open Access

ISSN: 2157-7013

+44 1300 500008

The clinical use of human culture- expanded autologous bone marrow mesenchymal stem cells transplanted on platelet-rich fi brin glue in the treatment of articular cartilage defects: A pilot study and preliminary results


International Conference & Exhibition on Cell Science & Stem Cell Research

29 Nov - 1 Dec 2011 Philadelphia Airport Marriott, USA

Dina Sabry

Accepted Abstracts: J Cell Sci Ther

Abstract :

Objective: To test the hypothesis that platelet-rich fi brin glue (PR-FG) can be used clinically as a scaff old to deliver autologous culture-expanded bone marrow mesenchymal stem cells (BMMSCs) for cartilage repair and to report clinical results 1 y aft er implantation of MSCs PR-FG. Patients and Methods: Autologous BM-MSCs were culture expanded, placed on PR- FG intraoperatively, and then transplanted into 5 full-thickness cartilage defects of femoral condyles of 5 patients and covered with an autologous periosteal fl ap. Patients were evaluated clinically at 6 and 12 mo by the Lysholm and Revised Hospital for Special Surgery Knee (RHSSK) scores and radiographically by x-rays and magnetic resonance imaging (MRI) at the same time points. Repair tissue in 2 patients was rated arthroscopically aft er 12 mo using the International Cartilage Repair Society (ICRS) Arthroscopic Score. Study Design: Case series; level of evidence 4. Results: All patients? symptoms improved over the follow-up period of 12 mo. Average Lysholm and RHSSK scores for all patients showed statistically signifi cant improvement at 6 and 12 mo postoperatively ( P < 0.05). Th ere was no statistically signifi cant diff erence between the 6 and 12 mo postoperative clinical scores ( P = 0.18). ICRS arthroscopic scores were 8/12 and 11/12 (nearly normal) for the 2 patients who consented to arthroscopy. MRI of 3 patients at 12 mo postoperatively revealed complete defect fi ll and complete surface congruity with native cartilage, whereas that of 2 patients showed incomplete congruity

Biography :

Dina Sabry has completed his M.D at the age of 33 years from Cairo University. I have published more than 25 papers in reputed journals

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