Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Anna Szemik-Hojniak
University of Wroclaw, Poland
Keynote: J Pharma Care Health Sys
The remarkable properties of functionalized styryl dyes as the stilben derivatives containing the variously substituted (-C6H5- CH=C) core are the subject of continuing interest. Despite that different substituents are incorporated into the aromatic rings and are allowed to obtain a numerous push-pull type donor-acceptor systems widely used in modern technologies, nonetheless, as they are also the representatives of bioactive heterocycles, they find application in various aspects of medicine and pharmacology. These molecules, on the UV light irradiation find themselves in the electronic excited state and depending on the environmental conditions their physico-chemical properties significantly change. Keeping in mind the known biological relevance of heterocyclic N-oxides that may cause apoptosis in human cells (e.g., K562 ), we decided to investigate the trans-4 - [4 ��?- (N, N dimethylamino-styryl)] pyridine N-oxide (DPO),2-(4-methoxy-trans-styryl)quinoline-1-oxide (MSQNO) and its hybrid complex with the ZnTPP unit.DFT and TD DFT calculations shown that in protic media, the trans-DPO system is able to form the hydrogen bonded complexes, allowing to find new applications in Biochemistry and Pharmacology. In this talk, we will discuss the charge transfer process in the excited state, the photo physical properties of these three compounds via. a vis polarity of the solvent, and differences caused by a weaker electron donor (methoxy group) substitution in MSQNO relative to [(-CH3)2N] group in DPO. A focus on theoretical aspect will be referred to a strong reference to experiment.
Anna Szemik-Hojniak has completed her PhD in Radiochemistry from the University of Wroclaw and Postdoctoral studies in Physical Chemistry from Solvay Foundation (Belgium), KULeuven (Belgium) and Centre of Nuclear Researches (Strasburg, France). She is experienced researcher and academic teacher and occupies with Organic Molecular Photophysics. She has published more than 45 papers in reputed scientific journals and has been serving as a reviewer of many different scientific journals. In the years (2002-2011) she served as the INWES Board director (2002-2011) for INWES corporation- operational partner of UNESCO. In 2007, at the University of Wroclaw, Poland, she organized international workshop on, “Strategies of the Highly Skilled Global Workforce”. In 2011, she was awarded with Distinguished Service Award. Presently she is INWES-ERI Board director (headquarters-Ottawa, Canada). In 2014, she organized Mini Symposium on, “Photophysics of Electron and Proton Transfer” in the framework of ICCMSE2014 conference, in Athens (Greece).
Email: anna.szemik@chem.uni.wroc.pl