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Targeting delivery of etoposide to inhibit the growth of human gl | 3971
Drug Designing: Open Access

Drug Designing: Open Access
Open Access

ISSN: 2169-0138

+44 1223 790975

Targeting delivery of etoposide to inhibit the growth of human glioblastoma multiforme using lactoferrin- and folic acid-grafted poly(lactide-co-glycolide) nanoparticles


International Conference and Expo on Drug Discovery & Designing

August 11-13, 2015 Frankfurt, Germany

Yung-Chih Kuo and Yu-Chun Chen

Scientific Tracks Abstracts: Drug Des

Abstract :

Lactoferrin (Lf) and folic acid (FA) were crosslinked on poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) for transporting
etoposide across the blood–brain barrier (BBB) and treating human brain malignant glioblastoma. Lf- and FA-grafted PLGA NPs
(Lf/FA/PLGA NPs) were employed to permeate the monolayer of human brain-microvascular endothelial cells (HBMECs) regulated
by human astrocytes and to inhibit the multiplication of U87MG cells. Lf/FA/PLGA NPs showed a satisfactory entrapment efficiency
of etoposide and characteristics of sustained drug release. When compared with PLGA NPs, the permeability coefficient for etoposide
across the BBB using Lf/FA/PLGA NPs increased about twofold. The antiproliferative efficacy against the growth of U87MG cells was
in the following order: Lf/FA/PLGA NPs > FA/PLGA NPs > PLGA NPs > free etoposide solution. In addition, the targeting ability
of Lf/FA/PLGA NPs was evidenced by immunostaining of Lf receptor on HBMECs and folate receptor on U87MG cells during
endocytosis. Lf/FA/PLGA NPs with loaded etoposide can be a promising anticancer pharmacotherapy to enhance the delivery of
etoposide to malignant brain tumors for preclinical trials.

Biography :

Yung-Chih Kuo is a professor at the Department of Department of Chemical Engineering, National Chung Cheng University. His research interests are focused on
biomaterials, drug delivery system, tissue engineering, blood–brain barrier, stem cell differentiation, nerve regeneration, cancer therapy, Alzheimer’s disease treatment,
biophysics, and colloid and interface science. In these fields, he has authored or coauthored over 100 SCI journal papers. He won Young Scholar Award in 2003 and
Outstanding Research Award in 2010-13. He is also an associate editor of J. Taiwan Inst. Chem. Eng. (Impact factor 2.637) and an editorial board member in 11 international
journals.

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