Journal of Proteomics & Bioinformatics
Open Access

Synthesis, structural analysis and biological activity of a dioxovanadium (V) complex incorporating Pyridoxal-thiosemicarbazone (PLTSC) ligand

6^th International Conference & Expo on Proteomics

March 29-31, 2016 Atlanta, USA

Violeta Jevtovic

University of Nizwa, Oman

Posters & Accepted Abstracts: J Proteomics Bioinform

Abstract :

The structure of the title compound C9H12V1N4O5S1, is an interesting metal complex with a Schiff base ligand derived from thiosemicarbazide and pyridoxal (pyridoxal is a 3-hydroxy-5hydroxymethyl-2-methylpyridine-4-carboxaldehyde). Ligand pyridal-thiosemicarbazone (PLTSC; H2L) is a tridentate ONS ligand. The V (V) environment is best described as a square pyramid. The equatorial plane is formed by the tridentate ligand and a two molecule of oxygen. This compound crystallizes in monoclinic symmetry, in space group P 21/c, with lattice constants: a=6.3789(2) �?º, b=8.8414(2) �?º, c=23.3578(7) �?º, �?±=90�?°, �?²=91.3963(11)�?°, �?³=90�?°, V=1316.95 �?�?3. The asymmetric unit consists of a tridentate ONS monodeprotonated ligand chelating the VO2+ and two water molecules. The well-separated complex units of [VO2 (PLTSC-H)] and H2O are connected by hydrogen bonds. Penta-coordinated vanadium (V) ion is in the equatorial plane surrounded by the ONS set of the ligand atoms and an oxygen atom. The V complexes shows a broad spectrum of antibacterial activity towards both Gram negative (Escherichia coli, Pseudomonas aeruginosa) and Gram positive (Staphylococcus aureus, Bacillus cereus) bacteria, reveals that the antibacterial mechanism is not dependant on the structural features of the bacterial cell wall.

Biography :

Email: violeta@unizwa.edu.om