Sang Hyun Park1, 2, Jongho Jeon1, So-Young Ma1, Dae Seong Choi1, Beom-Su Jang1, 2, Jung Ae Kang1, You Ree Nam1 and Seonhye Yoon1, 2
1Korea Atomic Energy Research Institute, Republic of Korea 2Korea University of Science and Technology, Republic of Korea
Posters-Accepted Abstracts: J Pharma Care Health Sys
The flavonone hesperetin and hesperidin are widely found in a large number of citrus fruits including sweet orange, mandarin, lemon, and lime. Especially, the composition of hesperetin can reach more than 40% on a dry weight basis of a few immature fruits and high concentrations of hesperetin were also found in orange and grapefruit peel. Hesperetin showed a wide range of pharmacological effects such as anti-inflammatory, antioxidant, anticancer, antiviral, antiallergic, and neuroprotective compounds. Radiolabeled hesperetin was synthesized to investigate its in vivo behavior. An optimized labeling method was established to provide two isomers of 123I-labeled hesperetin with high radiochemical purities as well as radiochemical yields. Both 123I-labeled products were orally administered to normal ICR mice. The initial result showed that most radioactivity was detected in the stomach and the intestines. A portion of 123I-labeled hesperetin was absorbed from the small intestine to blood stream and then it was distributed in organs. The results in the present study provided an efficient radiolabeling method of flavonoid and quantitative evaluation for organ distribution of orally administered hesperetin.
Sang Hyun Park received his PhD from the Department of Chemistry, Stevens Institute of Technology, NJ, USA in 1996. He worked for Ohsung Chemical Co. Ltd. (1997-1998) and the Korea Advanced Institute of Science and Technology (1999-2001). In the interval, since 2001, he has been employed by the Korea Atomic Energy Research Institute as a Researcher. His current research interests are in the fields of chemical sensors, biosensors, and drug discovery.
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