Synthesis of novel thiazolidinedione derivatives and evaluation o | 41061
Organic Chemistry: Current Research

Organic Chemistry: Current Research
Open Access

ISSN: 2161-0401

+44 7868 792050

Synthesis of novel thiazolidinedione derivatives and evaluation of their antiviral activity

4th European Organic Chemistry Congress

March 01-03, 2018 | London, UK

Basant M Saleh, Zakaria K Abdel Samii, Eatedal H Abd Elal and Amany H Ghanium

Zagazig University, Egypt

Posters & Accepted Abstracts: Organic Chem Curr Res

Abstract :

We previously identified one large molecular structure targeting the HIV-1 gp41, 2-Aryl 5-(4-Oxo-3-phenethyl-2thioxothiazolidinylidenemethyl)furan, which acts as lead compound for our novel synthetized drugs. On the basis of molecular docking analysis, we designed a series of 5-benzylidene-3-phenethylimidazolidine-2,4-dione. Novel thiazolidinedione derivatives were synthesized starting from hydantoin and thiohydantoin. 5-benzylidene-3-phenethylimidazolidine-2,4-diones were synthetized by alkylation followed by a Knoevenagel condensation and tested for their anti-HIV-1 activity and cytotoxicity on MT-2 cells. The synthesized compounds were characterized by 1H NMR, 13C NMR, mass spectroscopy, high resolution mass spectroscopy, IR and physical data.