Kotehol latha and S H Shreedhara
Kuvempu University, India
Scientific Tracks Abstracts: Drug Des
The 3-[(6-nitro-1,3-benzoxazol-2-yl) amino]-2-phenyl-1,3-thiazolidin-4-one derivatives 7(a-j) have been synthesized by reacting compounds 2-[2-benzylidenehydrazinyl]-6-nitro-1,3-benzoxazole derivatives (a-j) with thioacetic acid in dioxane using ZnCl2 as catalyst. The chemical structures of the compounds were elucidated by IR, 1H NMR, 13C NMR and mass spectral studies. The organisms such as Escherichia coli (ATTC-8739), Staphylococcus aureus (ATTC-6538), Vibrio cholera (ATTC-9027), Bacillus subtilis (ATTC-6633), Staphylococcus epidermidis (ATTC-12228) and Salmonella typhimurium (ATTC23564) have been used to study the antimicrobial activity of synthesized compounds. MIC was done with effective result. The antioxidant activity has been carried out to know the scavenging effect of targeted molecules and the results were supported by the in silico molecular docking studies.
Kotehol latha is an Assistant Professor in Sahyadri Science College, Kuvempu University, India. She has compelted her Master of Science degree in Organic Chemistry.