GET THE APP

Synthesis of arylpyrrole chalcone hybrids as anti-plasmodial and | 32184
Journal of Pharmaceutical Care & Health Systems

Journal of Pharmaceutical Care & Health Systems
Open Access

ISSN: 2376-0419

+44 1300 500008

Synthesis of arylpyrrole chalcone hybrids as anti-plasmodial and anti-trypanosomal agent


4th African Pharma Congress

June 20-21, 2016 Cape Town, South Africa

Ayanda Zulu

Rhodes University, South Africa

Posters & Accepted Abstracts: J Pharma Care Health Sys

Abstract :

Series of arylpyrrole chalcone hybrids were synthesized by Claisen Schimdt condensation of appropriate acetophenones with appropriate aromatic aldehydes, in the presence of aqueous solution of NaOH and methanol at room temperature. Synthesized chalcones were evaluated for their P. falciparum and trypanocidal activities. These compounds were found to have low cytotoxicity against human cells and showed some significant activity against trypanosome and little to no activity against P. falciparum strain with the chloro substituted chalcone being the most potent anti-trypanosomal agent of the entire series. Characterization of these compounds was carried out by means of their IR, 1H and 13C NMR, HRMS and elemental analysis.

Biography :

Email: azulu50@gmail.com

Top