Journal of Developing Drugs
Open Access

Synthesis, characterization and investigation of biological and cytotoxic activity of chelated compounds of copper, cobalt and nickel with N, S donor

International Conference and Exhibition on Pharmaceutical Development and Technology

April 24-26, 2017 Dubai, UAE

Shashikant H Gaikwad

Shri Shivaji Mahavidyalaya, India

Posters & Accepted Abstracts: J Develop Drugs Res

Abstract :

The new schiff base ligands 4-(4��?-nitrobenzylideneimino)-3-methyl -5-mercapto-1,2,4-triazole and their Co(II), Ni(II) and Cu(II) metal complexes were synthesized and characterized by elemental, various spectroscopic (UV-vis., IR) thermal and magnetic moment measurements. The ligand was synthesized by condensation of 4-amino-5-mercapto-3- methyl-1,2,4-triazole with 2/3/4-nitrobenzaldehyde. On the basis of electronic spectral data and magnetic susceptibility measurements the octahedral geometry has been proposed for all the Co(II) and Ni(II) complexes and square planer for Cu(II) complexes. The ligand and metal complexes have been screened for their antimicrobial activities against bacteria (Staphylococcus aureus, Pseudomonas aeruginosa) and fungi (Aspergillus niger and Candida albicans). Further the material was also screened for anticancer activity on human cancer cell lines such as breast (MCF7), lung (NCI-H226), prostate (PC-3) and ovary (OVCAR-3) by using sulforhodamine-B(SRB).

Biography :

Email: rasayanshg@gmail.com