Journal of Cell Science & Therapy
Open Access
ISSN: 2157-7013
ISSN: 2157-7013
Yemataw Addis Alemu
Debre Tabor University, Ethiopia
Posters & Accepted Abstracts: J Cell Sci Ther
The discovery of novel active compounds with new mechanisms of action, higher efficacy and improved selectivity is a matter of urgency to multi drug resistance and toxicity problems associated with many therapeutic drugs. In the current work, S-methyl dithiocarbazate Schiff base: SalSmdt, Mp(Smdt)2, VanSmdt, PySmdt and their Zn(II) complexes: Zn[(SalSmdt) (H2O)]â�?0.5H2O, Zn2[(Mp(Smdt)2) (CH3COO)], Zn[(VanSmdt) (H2O)] and Zn[(PySmdt) (CH3COO)]â�?1.5H2O were synthesized. Additionally, Zn[(phen)2(NO3)2]â�?2H2O, Zn[(aminophen)2(NO3)2]â�?1.5H2O and Zn[(Mephen)2(NO3)2]â�?3.5H2O complexes were developed by reaction of Zn(II) with 1,10phenanthroline (phen), 4,7-dimethyl-1,10-phenanthroline (Mephen) and 5-amino-1,10phenanthroline (aminophen). All compounds were characterized by elemental analysis, FTIR, UVVis, NMR, MS and fluorescence spectroscopies. The characterization suggests that the Schiff base ligands coordinate the metal ion through the phenolateâ�?�?O, the imine-N and the sulfur atom in the thiol form. The stability of the compounds in buffered aqueous media (5 % DMSO and 95 % PBS, pH 7.4) was evaluated and all compounds are stable at least for three hours. Cytotoxicity studies with several tumor cell lines (PC-3, MCF-7 and CACO-2) are ongoing. The results obtained for the Schiff bases are promising since the IC50 values ranged from 4.41 to 28.99�?¼M. The phenanthroline ligands and their corresponding Zn complexes showed very high cytotoxicity towards A2780 ovarian cancer cells, with the Zn complexes showing slightly higher activity than the ligands. yematawaddis@yahoo.com