Organic Chemistry: Current Research
Open Access
ISSN: 2161-0401
ISSN: 2161-0401
Mpelegeng Victoria Bvumbi
University of Venda, South Africa
Posters & Accepted Abstracts: Organic Chem Curr Res
Malaria together with six other diseases (diarrhoea, HIV/AIDS, TB, measles, hepatitis B and pneumonia) account for 85% of global infectious diseases burden and therefore impose great socio-economic burden on humanity. There are drugs in the market which can be used to treat or prevent malaria. The most widely used drugs to treat malaria are quinine and its derivatives as well as antifolate combination drugs. The major obstacle in the treatment of malaria is the drug resistance in malarial parasites and the resistance has been reported for almost all the antimalarial drugs. There is an interesting class of compounds which were promising in the fight against malaria and these are called triazines. Whilst more work has been done and reported on triazine, especially on 1,3,5-triazines class, not much has been done on 1,2,4-triazine as antimalarial agents. Due to their resemblance to the pyrimethamine type of pyrimidine antimalarial, the 3,5-diamino-1,2,4-triazine derivatives are believed to have more activity against strains of Plasmodium Falciparum, hence the starting compound 1. The synthetic approaches towards 2 and 3 and their preliminary biological data will be described in this presentation.