Synthesis and biological evaluation of new 1,3,4-oxadiazole deriv | 42051
Organic Chemistry: Current Research

Organic Chemistry: Current Research
Open Access

ISSN: 2161-0401

+44 1478 350008

Synthesis and biological evaluation of new 1,3,4-oxadiazole derivatives as anticancer agent

11th Global Experts Meeting on Chemistry And Computational Catalysis

May 18-19, 2018 Singapore

Ishan Pachal and Ashish Patel

Parul University, India

Scientific Tracks Abstracts: Organic Chem Curr Res

Abstract :

Objective: The present work deals with the design, synthesis, characterization of novel substituted 2-(4-phenylamino)-N-(5((4-nitrophenoxy)methyl)-1,3,4-oxadiazol-2-yl) acetamide and substituted N-(5-(phenoxymethyl)-1,3,4-oxadiazol-2-yl)-2(phenylamino) acetamide derivatives in treatment of lung cancer. Methods: Novel 1,3,4-oxadiazole derivatives were synthesized and characterized by melting point, TLC, IR Spectroscopy, Mass spectroscopy and 1H NMR. In vitro biological evaluation was performed on NCI-H2066 cell line for different concentrations 10-1000 �?µM by telomeric repeat amplification protocol (TRAP) assay. Results: Novel substituted 2-(4-phenylamino)-N-(5-((4-nitrophenoxy)methyl)-1,3,4-oxadiazol-2-yl) acetamide and substituted N-(5-(phenoxymethyl)-1,3,4-oxadiazol-2-yl)-2-(phenylamino)acetamide were synthesized and characterized using spectral and analytical data. All compounds have shown considerable percentage inhibition of cell growth with respect to Bevacizumab, but compound which is nitro substituted and chloro substituted is equipotent with respect to activity as compared to standard Bevacizumab. Conclusion: Among all synthesized derivative, p-nitro substituted derivative and p-chloro substituted showed highest activity against humanng cancer cell line NCI-H2066 by telomeric repeat amplification protocol assay.

Biography :

Ishan Panchal has obtained his PhD from Gujarat Technological University, India. He is as an Assistant Professor at the Department of Pharmaceutical Chemistry in Parul Institute of Pharmacy, Parul University, India. He has published more than 19 papers in reputed journals and has published two monographs.