Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
ISSN: 2167-0501
Prashant L. Pingale and Ravindra R. P.
Accepted Abstracts: Biochem & Pharmacol
Bioenhancers are agents when combined with an active drug lead to potentiate the pharmacological effect of the drug but themselves do not any therapeutic effect. Recent development in bioavailability enhancement of drugs by herbal compounds has produced a new shift in the way of therapeutics. For the last decade, many novel carriers like liposomes, microspheres, nanoparticles, transferosomes, ethosomes, and lipid based systems have been reported for successful modified delivery of various drugs. The major problems associated with the anti-TB drug therapy include loss of efficacy through bacterial resistance, side effects, and low patient compliance. In the cited research work, we have attempted to solve the above mentioned problems by simultaneous use of both the concepts of microsphere drug delivery (higher bioavailability and low toxicity) and herbal bioenhancers (greater bioavailability). We used isoniazid and rifampicin as a model drug used in TB therapy. Hydro-alcoholic extracts of Carum carvi and Ocimum sanctum were used as bioenhancers. The in-vitro drug release of different formulations was checked and compared. It was found that in-vitro drug release of the formulations where we used bioenhancer extract was found to be significantly increased as compared to formulations where bioenhancers were not used. Other parameters like percentage bioadhesion, permeability study using intestinal sac method, etc., were also studied.