Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Divya Pradipbhai Maheta
B K Mody Government Pharmacy College, India
Posters & Accepted Abstracts: J Pharma Care Health Sys
The present study evaluated the interaction between Metformin and Pterocarpus marsupium in combination on fructose induced diabetes in rat model. 10 weeks old male/female Spargue-Dawley rats (180-200gm) were selected for experiment and divided into seven groups (n=6). Fructose was administered as a 21% solution in drinking water to all the groups for 8 weeks. After diabetes induction, treatment received by each group for 14 days was as follows: Group 1 (Control) received Vehicle only, Group 2 (disease control) received 21% fructose solution orally, Group 3 received Metformin (50mg/kg; p.o), Group 4 received hydro-alcoholic extract of Pterocarpus marsupium (300mg/kg; p.o), Group 5 (MET 12.5 + HAPM) received Metformin (12.5mg/kg; p.o) with hydro-alcoholic extract of Pterocarpus marsupium (300mg/kg; p.o), Group 6 (MET 25 + HAPM) received Metformin (25mg/kg; p.o) with hydro-alcoholic extract of Pterocarpus marsupium (300mg/kg; p.o) and Group 7 (MET 50 + HAPM) received Metformin (50mg/kg; p.o) with Hydro-alcoholic extract of Pterocarpus marsupium (300mg/kg; p.o). At the end of study, blood glucose, serum insulin, lipids parameter, liver glycogen and reduced glutathione was evaluated. Metformin and hydro-alcoholic extract of Pterocarpus marsupium both demonstrated anti-diabetic and antihyperlipidemic effect. Results showed that combination treatment group showed significant (p<0.05) normalization of blood glucose, serum insulin, lipids parameter, liver glycogen and reduce glutathione as compared to disease control group and only Metformin treated group. Combination Metformin and hydro-alcoholic extract of Pterocarpus marsupium showed significant anti-diabetic activity than Metformin alone this may help to reduced dose and thus reduce side effect and increase sensitivity of Metformin.
Divya Pradipbhai Maheta is currently studying in Postgraduate degree in Pharmacology at B K Mody Government Pharmacy College, Rajkot, India (Gujarat Technological University). She has finished her graduation from same institute.