Journal of Proteomics & Bioinformatics
Open Access

Structure based pharmacophore modeling for design of riboswitch based potent inhibitors for Vibrio cholerae

7^th International Conference on Proteomics & Bioinformatics

October 24-26, 2016 Rome, Italy

Somdutt Mujwar

Maulana Azad National Institute of Technology, India

Posters & Accepted Abstracts: J Proteomics Bioinform

Abstract :

Cholera pandemics are caused by facultative pathogenic Vibrio cholerae bacteria persisting in the countries having warmer climatic conditions as well as the presence of large water bodies with huge amount of organic matter, it is responsible for the millions of deaths annually. Presently, the available therapy for cholera is Oral Rehydration Therapy (ORT) with an antibiotic drug. Excessive utilization of life saving antibiotics drugs leads to the development of resistance by the infectious microorganism against the antibiotic drugs resulting in loss of effectiveness of these drugs. Also, many side effects are associated with the use of these antibiotic drugs. This riboswitch is explored as an alternative drug target for Vibrio cholerae bacteria to overcome the problem of drug resistance as well as side effects associated with the antibiotics drugs. The bacterial riboswitch is virtually screened with 24407 ligands to get possible drug candidates. The 10 ligands showing best binding with the riboswitch are selected to design a pharmacophore which can be utilized to design lead molecules by using the phenomenon of bioisosterism.

Biography :

Email: simplysom4u@gmail.com