Organic Chemistry: Current Research
Open Access
ISSN: 2161-0401
ISSN: 2161-0401
Preetismita Borah
CSIR-Central Scientific Instruments Organisation, India
Posters & Accepted Abstracts: Organic Chem Curr Res
A hybrid approach to new molecular scaffolds is currently finding considerable importance among organic chemists for the rapid synthesis of a library with a diverse array of compounds. A hybrid compound or a drug which consists of two therapeutically active chromophores in one single molecule are basically designed interacting as one single molecule with multiple targets or to enhance its effect through the action on another bio target or to counterbalance the known side effects associated with the other part of the hybrid molecule. 1,2 Nature synthesizes many of such hybrid systems bearing potential biological activities through mixed biosynthetic pathways.2,3 Considering the importance of steroids as an important class of compounds due to their rigid frame work with varying level of functionalization, profile with broad biological activities, high ability to penetrate cells and bind to membrane receptors, we will present here a review on different approaches to favour steroids as building platforms to synthesize designed molecular hybrid systems through linkage with different bioactive compounds, drugs and other functional molecules. In the present work, synthesis of an important class of Steroid-peptide conjugates based on aminosteroid will be presented through the application of MW-irradiated Ugi-4CR.4,5.