Spinosad induced cytogenotoxic effects on the mosquito fish, Poec | 50882
Journal of Clinical Toxicology

Journal of Clinical Toxicology
Open Access

ISSN: 2161-0495

+44 1478 350008

Spinosad induced cytogenotoxic effects on the mosquito fish, Poecilia reticulata (guppy)

International Toxicology Summit & Expo

November 26-28, 2012 Hilton San Antonio Airport, USA

Lucian Obinnaya Chukwu

Scientific Tracks Abstracts: J Clinic Toxicol

Abstract :

Background : The cytogenotoxic potential of the naturally derived Spinosad was investigated on the mosquito fish, Poecilia reticulata. Methods : Blood samples were collected from the gill epithelial cells of Poecilia reticulata exposed in vivo to three different concentrations of Spinosad. The frequencies of micronucleus and other nuclear abnormal cells as well as, normo-chromatic cells from treated and untreated media were evaluated after sacrificing the fish at sampling times of 1, 3, 7, 14, 21 and 28 days. Results : The induction of micronucleus, nuclear abnormal cell and normo-chromatic cells relied highly on concentration increase (P<0.001). Polychromatic erythrocytes were more sensitive than binucleated cells, and this occurred with increasing concentrations (P<0.01). The ratio of polychromatic cell to normo-chromatic cells increased significantly by concentration and time of exposure (P<0.05). Conclusion : At low concentrations, the naturally derived Spinosad inhibited mitotic division that was non-mutagenic in Poecilia reticulata.

Biography :

Lucian Obinnaya Chukwu is the current Dean, School of Postgraduate Studies and former Head, Department of Marine Sciences, Faculty of Science, University of Lagos, Akoka - Yaba, Lagos Nigeria. He was trained at the University of Lagos where he obtained his doctorate degree in Ecosystem Health and Pollution Management and later proceeded to the Coastal Resources Institute, University of Rhode Island, USA for his post doctoral training in Integrated Coastal Management. He has been teaching at the University of Lagos for over twenty years. Professor Chukwu has been a Consultant to many national and international agencies including the Federal Ministry of Environment where he has participated in various aspects of Environmental Impact Assessment Studies (EIA). He has been Project/Team Leader in several EIA Studies in line with World Bank Guidelines and IFC Performance Standards in Aviation, Infrastructure, Ports and Harbours and the Oil and Gas sub sector. He has participated and served as resource person in several national and international conferences, workshops and training programmes in Europe, North America, Middle East, Africa and Asia. He belongs to several professional associations including Science Association of Nigeria (SAN); Nigerian Environmental Society (NES); Environmental Practitioners Association of Nigeria (EPAN); Biotechnology Society of Nigeria (BSN); Nigerian Association for Aquatic Sciences (NAAS); International Water Association (IWA) UK and International Association for Environmental Impact Assessment (IAIA). He is member Board of Trustees of DOAM Foundation, a non-governmental, non-profit organisation that is committed towards touching the lives of under-privileged children in society and accident victims