Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Suhera M Aburawi, Habiba A ElJaafari, Soad A Treesh, Abdulssalam M Abu-Aisha, Faisal S Alwaer, Reda A Eltubuly and Medeha Elghedamsi
Scientific Tracks Abstracts: J Clin Toxicol
Introduction: Infertility is a source of psychological and sometimes social stress on parents who desire to have children. Formaldehyde
is used chiefly as disinfectant, preservative and in the chemical synthesis. The medical uses of formaldehyde are limited, but focused
especially on laboratory use. Selenium is an essential trace of mineral element for human; it is essential for sperm function and male
fertility. Selenium deficiency has been linked to reproductive problems in animals.
Objectives: To investigate the prophylactic and curative effect of selenium on male infertility induced by formaldehyde using male
albino mice.
Method: Forty male albino mice were used, weight 25-30 gm. Five groups of male mice (n=8) were used. Group 1 was daily
administered water for injection (5 ml/kg) for five days, group 2 was daily administered selenium (100 μg/kg) for five days, group
3 was daily administered formaldehyde (30 mg/kg) for five days, group 4 (prophylaxis) was daily administered a combination of
formaldehyde and selenium for five days, while group 5 (curative) was daily administered formaldehyde for five days followed by daily
administration of selenium for the next five days. Intraperitoneal administration was adopted. At the end of administration, seminal
fluid was collected from vas deferens. Sperm count, morphology and motility were scored; Histopathological screening of genital
system was carried out. SPSS software was applied for comparing groups.
Results & Conclusion: It was found that formaldehyde toxicity did not change the sperm count and percentage of motile sperm;
unhealthy sperm was increased, while healthy sperm was decreased. Formaldehyde produces degeneration/damage to the male mice
genital system. Selenium alone produces an increase in sperm count, volume of seminal fluid and the percentage of motile sperm.
Selenium has prophylactic and curative effects against formaldehyde-induce genital system toxicity. Future work is recommended to
find out if selenium protective effect is through antioxidant or other mechanisms.
Suhera M Aburawi has completed her PhD at Cairo University (1999), and MPhil at London Hospital Medical College (1984). She has published more than 23 papers in
reputed journals, and contributed to more than 24 conference papers. She was invited, by several journals, to review submitted manuscripts. She also contributed the
chapter on Libya in several editions of D’Vanzo, C.E. and Geissler, E.M. (eds.), Cultural Health Assessment, Mosby Inc.