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Dorsa Daneshbakhsh,Jinous Asgarpanah, ParvanehNajafizadeh, Tayebeh Rastegar and Zahra Mousavi
Islamic Azad University, Iran
Posters & Accepted Abstracts: J Clinic Toxicol
Background: Mentha mozaffarianii is an endemic species from the Labiatae family, is
used in Iranian traditional medicine. This study evaluated the acute and repeated oral
toxicity of the Mentha mozaffarianii essential oil (MMEO) in rats and mice.
Aim & Methods: The aim of this study was to assess the toxicity profile of the MMEO. We administered the essential oil to 48 rats and mice of both sexes by gavage in acute and repeated models. In acute toxicity, the animals were administered the MMEO (2000 mg/ kg) and were monitored for 14 days. In the repeated toxicity, the MMEO was administered (100 mg/kg) daily for four weeks. On the 28th day, all the animals were scarified, and blood and tissue samples were prepared. All the clinical, biochemical, and histopathological changes were assessed and compared with those in the controls. Statistical significance was determined by one- and two-way analyses of variance, followed by the Turkey test using GraphPad Prism 6.
Results: In the acute test, there was no mortality; therefore, the oral LD50 value determined in the mice and rats of both sexes was greater than 2000 mg/kg. In the repeated test, the animals received the MMEO and there was no mortality. In the biochemical analysis, there were significant increases in blood glucose, cholesterol, ALT, AST, ALP, and TSH in the female rats and also BUN in the male rats. The histopathological studies revealed evidence of microscopic lesions in the liver, kidney, stomach, and small intestine tissues of the MMEO group.
Conclusion: The results indicated that the acute toxicity of the MMEO in the mice and rats was of a low order and it revealed slight tissue damage to several organs when given subchronically at a dose of 100 mg/kg.
Dorsa Daneshbakhsh has completed her education in Islamic Azad University of Pharmaceutical Sciences. Currently, she is working as a Faculty of Pharmacy in Islamic Azad University and she is continuing her earch in Herbal Medicines Research Center. She has published her research works in many international journals and attended many conferences.