Rosmarinic acid mediates glucose transporter protein (GLUT-4) by | 52581
Journal of Clinical Toxicology

Journal of Clinical Toxicology
Open Access

ISSN: 2161-0495

+44 1478 350008

Rosmarinic acid mediates glucose transporter protein (GLUT-4) by upregulating C-peptide and insulin in diabetic rats

4th Global Summit on Toxicology

August 24-26, 2015 Philadelphia, USA

Aditya Arya, Ataul Karim Khan, Nayiar Shahid and Hapipah Mohd Ali

Scientific Tracks Abstracts: J Clin Toxicol

Abstract :

The study aimed to investigate the potential role of Rosmarinic acid (RA) in the management of diabetes. RA is an ester of caffeic
acid found in various plants which have reflected beneficial effects on different disorders. In our study design, the normal rats
were treated with different doses of RA to evaluate acute toxicity. Further on the basis of acute toxicity results, two doses of RA were
selected for antidiabetic study on STZ-nicotinamide induced diabetic rats. Diabetic rats were fed 50 and 100 mg/kg body weight of
RA daily for 90 days and weekly measured with certain biochemical parameters, blood glucose, insulin, C-peptide, lipid profiles and
body weight. At the end of the study period, all the group animals were sacrificed and the blood glucose, insulin, C-peptide, and
HbA1c levels were determined in the serum of rats. In addition, histology of pancreas and the expression of glucose transporters
(GLUT 1, 2 and 4) proteins were assessed in skeletal muscles and pancreatic tissues. The overall study result demonstrated that RA
has potentially normalized the elevated blood glucose levels and significantly improved serum insulin, C-peptide and HbA1c levels
thereby reducing cholesterol and bad lipids. Furthermore, the histology result reported recovery in the structural degeneration in
the pancreatic tissues, and the western blot analysis showed the significant increase in the GLUT-2 and GLUT-4 protein expression
in the skeletal and pancreatic tissues. Altogether, we may postulate that the translocation of glucose transporter proteins (GLUT-4)
accelerates the insulin-mediated glucose uptake in muscle and adipose tissue. Thus, we may conclude that RA could be the potential
targets for the management of diabetic complications and needs further in depth mechanistic studies at molecular level.

Biography :

Aditya Arya is a Senior Lecturer of Pharmacology at Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. He has received PhD in Pharmacology from the
University of Malaya and have published over 30 peer-reviewed papers in reputed Journals. He has been serving as a reviewer for many ISI Journals including editorial
board member.His research emphasizes on cellular and molecular Pharmacology, specifically to evaluate the co-relationship between inflammation, cancer and diabetes.
He is expert in designing, development and mechanistic prediction of drug molecules on the living system and theirrole on G-protein-coupled receptors in islet function and
stimulus-response coupling in mouse and human islet β-cells. Moreover, to detect and identify novel insulin secretagogues.