Richard L Summers and Stephanie C Tanner
University of Mississippi Medical Center, USA
Posters & Accepted Abstracts: Biochem Pharmacol (Los Angel)
Statement of the Problem: Clinical studies that examine the outcomes of different treatments have guided the development
of standards of care for the practice of medicine. While the evidences of these clinical trials has led to an improved practice of
medicine, they focus on the outcome likelihoods for the population of patients as a whole and therefore treatment guidelines
have evolved into a one-size-fits-all methodology. Recently, the modern methods of precision/personalized medicine have
emerged as the course of medical practice for the future. The discovery of biomarker targets for the pharmacologic strategies
of precision medicine will be critical to the development of this practice.
Methodology: Developing precision/personalized medicine systems will require an improved capacity to link biologic
biomarkers with basic clinical, demographic and socioeconomic phenotypes. Such biomarkers can then be used as targets for
patient-specific pharmacologic treatment strategies. A process that back tracks clinical treatment outcomes or adverse events
to biologic materials banked in a prospectively instituted biorepository system can be used in the discovery of these potential
Results: A software interface was used to link information from the electronic health record (Epic) and other salient data
contained within the enterprise data warehouse with samples in the biobank at the University of Mississippi Medical Center.
Researchers analyzing the epidemiologic characteristics of the data warehouse can identify cohorts of patients with specific
responses to prescribed pharmacologic treatments. The biobanked biologic specimens that are associated with the individuals
in these cohorts can then be recovered for an analysis of their pharmacogenetics and other omics as potential biomarker
Conclusion: The new precision medicine approach to clinical practice represents a shift in the philosophy of treatment
schemes that will require a greater focus on the translation of basic biomedical research to practical patient applications.
Linking biobanked specimens to observed outcomes in clinical cohorts will be critical to the discovery of biomarker targets
that facilitate decisions regarding precision pharmacologic strategies.
1. Pauli C, Moch H and Rubin M A (2017) Establishment of a living biobank: improved guidance of precision cancer care with in vitro and in vivo cancer models. Pathologe. 38(2):160ΓΆΒ?Β?168.
2. Ostrom Q T, Devine K, Fulop J, Wolinsky Y, Liao P, et al. (2017) Brain tumor biobanking in the precision medicine era: building a high-quality resource for translational research in neuro-oncology. Neurooncol Pract. 4(4):220ΓΆΒ?Β?228.
3. Vaught J (2016) Biobanking comes of age: the transition to biospecimen science. Annu Rev Pharmacol Toxicol. 56:211ΓΆΒ?Β? 28.
4. Somiari S B and Somiari R I (2015) The future of biobanking: a conceptual look at how biobanks can respond to the growing human biospecimen needs of researchers. Adv Exp Med Biol. 864:11ΓΆΒ?Β?27.
Richard L Summers, MD, FACEP is Associate Vice Chancellor for Research, University of Mississippi Medical Center Billy S Guyton Distinguished Professor and Chair Emeritus Department of Emergency Medicine Previous Lead Scientist for NASA Digital Astronaut Project. Richard L Summers, MD, FACEP is a native of Gulfport Mississippi and graduated from the University of Southern Mississippi magna cum laude in mathematics in 1977. He received his medical degree from the University of Mississippi Medical Center in 1981 after which he entered their residency program in internal medicine. Summers then began graduate studies and completed a research fellowship under Dr. Arthur C Guyton and Dr. Thomas G Coleman in the Department of Physiology and Biophysics. Since 1988 he has been a faculty member at the University of Mississippi Medical Center in various roles including Chairman of the Department of Emergency Medicine. He currently serves as the Associate Vice Chancellor for Research and holds joint appointments in the Department of Emergency Medicine and the Department of Physiology and Biophysics and is a Fellow of the American College of Emergency Physicians.
E-mail: [email protected]