Aaon Nana Frimpong
Cyprus International University
Posters & Accepted Abstracts: J Clin Exp Cardiolog
When a thrombus forms within an artery, this is known as an arterial thrombosis. Clot formation is typically triggered by the rupture of an atherosclerotic plaque, a highly thrombogenic event, with platelets rapidly recruited to the site. The fibrin content of the clot slowly increases as the thrombus extends into the arterial lumen. Thus, an arterial thrombus is typically platelet-rich, fast growing and exposed to fast blood flow. AF-related thrombi are also categorized as arterial clots, but more closely resemble √Ę¬?¬?venous-type√Ę¬?¬? clots, fulfilling Virchow√Ę¬?¬?s triad for thrombogenesis. AF-related thrombi form in lowflow, low-pressure environments, producing slow-growing, fibrin-rich clots. Important risk factors for arterial thrombosis include: (1) Smoking (2) Obesity (3) High blood pressure (4) Increased levels of cholesterol (5) Diabetes (6) Increasing age (7) Family history (8) Physical inactivity (9) Increased concentrations of blood coagulation factors and (10) Blood serum lipid abnormalities. Incidence and prevalence in thrombogenesis is atherosclerotic lesions develop throughout the arterial system and, depending on the vascular bed most affected, disease can manifest as CAD, PAD or cerebrovascular disease. CAD is the most commonly diagnosed form of cardiovascular disease, in which atherosclerosis damages the coronary artery wall predisposing to thrombus formation. The symptoms and severity of ACS (unstable angina and MI) vary depending on the degree to which thrombi occlude the coronary arteries.The incidence and prevalence of the clinical manifestations of arterial thrombosis is high. The annual incidence (number of new and recurrent cases per year) of symptomatic or fatal MI and stroke in the US has been estimated to be 915,000 and 795,000, respectively. Estimates place the overall prevalence of MI in the US at 7.6 million and stroke at 6.8 million. Complications include arterial-type clots can result in MI and unstable angina (ACS events), ischaemic stroke and some manifestations of PAD, such as acute limb ischaemia. Thrombi characteristics are an important consideration for the development of treatment/prevention strategies (i.e. anticoagulant/antiplatelet).
Aaon Nana Frimpong is currently studying his Master’s from Cyprus International University.