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Research for cytochalasin b, phloretin, forskolin, and phlorizin inhibiting glucose transporter from staphylococcus epidermidis through molecular dynamics simulation
Journal of Chemical Engineering & Process Technology

Journal of Chemical Engineering & Process Technology
Open Access

ISSN: 2157-7048

Research for cytochalasin b, phloretin, forskolin, and phlorizin inhibiting glucose transporter from staphylococcus epidermidis through molecular dynamics simulation


JOINT EVENT ON 5th International Conference on Bioplastics and 6th World Congress on Biopolymers

September 07-09, 2017 | Paris, France

Xian-yang Zeng, Xi Zhao,A Lu Liu and Xu-ri Huang

Jilin University, China

Posters & Accepted Abstracts: J Chem Eng Process Technol

Abstract :

Glucose transport (GLUT) is vital to most living cells as a gate inserted in membranes controlling the source of both energy and carbon, glucose into cells. Previous work with human GLUTs identified several inhibitors of glucose transport: cytochalasin B, phloretin, forskolin, and phlorizin. Now the research focuses on Staphylococcus epidermidis glucose/H+ symporter (GlcPSe), which shares high sequence identity (27ΓΆΒ?Β?34%) and homology (49ΓΆΒ?Β?58%) with the human GLUTs, and tries to search the proof of inhibition in the aspect of thermodynamics and conformation through molecular dynamics simulation. Furthermore, we also discuss the protonation effect among the transport process.

Biography :

Xian-yang Zeng is now studying in Institute of Theoretical Chemistry, Jilin University for Doctor's degree.