Clinical & Experimental Cardiology
Open Access

Relationship between monocyte subsets, IL-6 and hs-CRP with the severity of coronary artery disease in stable Angina Pectoris patients

2^nd World Heart Congress

May 14-16, 2018 Tokyo, Japan

Abdelmohsen M Aboualia, Entsar R Mokhtar, Bothayna I Saleh and Hala M Nageb

Al-Azhar University, Egypt

Posters & Accepted Abstracts: J Clin Exp Cardiolog

Abstract :

Background: Monocytes are crucially involved in all stages of atherogenesis as cellular drivers of vascular inflammation hallmarking atherosclerotic disease. CD16+ monocytes are pro-inflammatory cells, whose proportion is related to the occurrence of coronary artery disease (CAD), intamedia thickness and plaque stability. Interleukin-6 (IL-6) and highly sensitive C reactive protein (hs-CRP) were also closely related to atherosclerotic disease. Objective: We investigated the relationship between the monocyte subsets, IL-6 and hs-CRP with the severity of CAD assessed by coronary angiography (CAG) in patients with stable angina pectoris (SAP) through their correlation with Gensini score. Methods: Our study included 45 SAP patients who underwent diagnostic CAG. 32 patients of them who diagnosed as CAD were subdivided into 2 groups: 17 patients with multiple-vessel disease (MVD) and 15 patients with single-vessel disease (SVD). The rest 13 SAP patients without CAD (non-CAD) were considered as a comparative group. Gensini score was used to assess the severity of CAD. Monocyte subsets were analyzed by flow cytometry and serum levels of IL-6 and hs-CRP were measured by ELISA. Results: The relative proportion of CD14+ CD16+ and CD14bright CD16+ was significantly higher in CAD patients, MVD and SVD as compared with non-CAD patients and in MVD more than SVD. Serum levels of IL-6 and hs-CRP were significantly increased in CAD patients, MVD and SVD when compared with non-CAD patients, but no significant difference between MVD and SVD. The proportion of CD14+ CD16+ and CD14bright CD16+ monocytes was positively correlated with Gensini score (r=0.667, P=0.000, r=0.695, P=0.000). Conclusion: Elevated proportion of CD14+ CD16+ monocytes subsets was associated with the severity of CAD in patients with SAP. abdelmohsen1@hotmail.com