Regulating the Acid-sensing ion channel1a with Psalmotoxin1 throu | 18394
Journal of Chemical Engineering & Process Technology

Journal of Chemical Engineering & Process Technology
Open Access

ISSN: 2157-7048


Regulating the Acid-sensing ion channel1a with Psalmotoxin1 through molecular dynamics simulation

JOINT EVENT ON 5th International Conference on Bioplastics and 6th World Congress on Biopolymers

September 07-09, 2017 | Paris, France

Xi Zhao, Lu Liu, Xian-yang Zeng and Xu-ri Huang

Jilin University, China

Posters & Accepted Abstracts: J Chem Eng Process Technol

Abstract :

Acid-sensing ion channel 1a(ASIC1a) is a cation channel activated by protons and causes Nerve death through central nervous system. Psalmotoxin1 is a gating modifier for ASIC1a. How the PcTx1 in complex with ASIC1a regulates the channel gating from the extracellular domain to the transmembrane domain is unclear. Here we used molecular dynamics (MD) simulations method to report the function of residues on PcTx1 and the path to change the ion pore. �?²1, �?²2, �?²10, �?±6, �?±7, �?²11 and �?²12 provide crucial the passageway to influence to channel gating through analyzing the PCA results and residues Arg27 is the main reason to stabilize the open state of the pore through researching the hydrogen bonds, combining with the correlation network analysis.

Biography :

Xi Zhao obtained his PhD in 2007 from Jilin University and was a visiting scholar from Department of Chemistry at University of California, Irvine. Now he is an associate professor of Institute of Theoretical Chemistry, Jilin University. His researches focus on biomolecular simulation. He has published more than 30 papers in reputed journals.