Gynecology & Obstetrics
Open Access

Prognostic significance of miR-34a in respect of NF-κB, p53 expression in different stage/grade of female genital and gonadal cancer

3^rd Annual Conference on Gynecologic Oncology & Preventive Oncology

July 20-21, 2017 Chicago, USA

Debarshi Jana

Institute of Post Graduate Medical Education & Research and Seth Sukhlal Karnani Memorial Hospital, India

Scientific Tracks Abstracts: Gynecol Obstet (Sunnyvale)

Abstract :

Female genital and gonadal cancer is first becoming commonest malignancy in female in urban population in India. Till now, most of the treatments are guided by the tumor parameters and many occasions the results of treatment have been unpredictable. This work aims to study various molecular factors and will try to link them with the tumor factors. This study has evaluated prognostic significance of miR-34a in female genital and gonadal cancer and correlated them with NF-�?ºB and p53 expression in cancer patients. In this hospital based study, female genital and gonadal cancer patients attend at OPD in our institute of Eastern India. miR-34a, NF-�?ºB and p53 protein expression was measured from cancer tissue sample by both Western Blot and RT-PCR techniques. Statistical significant risk of NF-�?ºB and p53 positive tumor was found in advance stage. It was concluded that miR-34a is an independent prognostic and predictive marker of Indian female genital and gonadal cancer. Thus, the study can result in a pioneering work in establishing new risk stratification system which will be of importance in selecting appropriate adjuvant therapy following surgery. No such host-tumor integrating study has come out from this subcontinent and therefore is of importance in establishing female genital and gonadal cancer guideline for general Indian population.

Biography :

Debarshi Jana is presently working as a Young Scientist (DST, New Delhi) at Department of G & O, Institute of Post Graduate Medical Education & Research and Seth Sukhlal Karnani Memorial Hospital, under Calcutta University, Kolkata, India and has completed his PhD in October 2014. He has published more than 14 papers in reputed journals and presented more than 26 papers in oral/poster presentations in various conferences.

Email: debarsheejana@gmail.com