Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Tushar A Gohil
Smt C V Gajera Mahila Pharmacy College, India
Posters-Accepted Abstracts: J Pharma Care Health Sys
The purpose of this study was to produce oral controlled release organogel of methimazole to lengthen drug retention time. This dosage form is associated with many advantages like solves problems of frequent dosing and patient incompliance. Preformulation studies and drug excipient studies were carried out for methimazole and excipient. Controlled release organogel were prepared by heating method. One factor response surface methodology was applied to formulate formulations (F1-F14) with different concentration of 12-hydroxy stearic acid and different rate of cooling (gradual cooling and rapid cooling) at five levels using quadratic model. Prepared formulations were subjected to various evaluation tests. The optimized batch was derived statically by using Design Expert 8.0. Controlled release organogel formulated using optimized formula was then evaluated for various parameters. Results of preformulation studies were observed between methimazole and excipients by Differential scanning calorimetry and Fourier transfer infrared spectroscopy. The drug release profile was 89.00% at 10 hr and 98.02% at 12 hr. The results showed significant bias between predicted and actual response for the optimized formula. The result of the present investigation suggested that organogel prepared by using 12-hydroxy stearic acid as an organogelator and soybean oil as base can be clearly useful for controlled release formulation to provide alternative in delivery of methimazole.
Email: gohil1313@gmail.com