Drug Designing: Open Access
Open Access
ISSN: 2169-0138
+44 1223 790975
ISSN: 2169-0138
+44 1223 790975
Mahdieh Heydarigoojani
TU University of Vienna, Austria
Posters & Accepted Abstracts: Drug Des
Purpose: In Atherosclerosis, vessels wall getting narrow and stiff. It is refers to buildup LDL(low density lipoprotein) and as a result, blood and nutrition can not pass through artery. Also Endothelial cells are injured and smooth muscle cells immigrate into the Intima. Therefore anticancer drugs would be appropriate choice for treatment. Curcumin and Docetaxel showed anti inflammatory and anti proliferative effects respectively. But their clinical application has been limited due to the fact that hydrophobicity and poor bioavailability. For this reason a potent mPEG-PCL micelle system was synthesized and release profile of Curcumin and Docetaxel from drug- loaded micells was characterized. Methods: In this study, monomethoxypoly(ethylene glycol)-poly(�?�?-caprolactone) (mPEG-PCL) copolymer through ring opening polymerization was synthesized. Core-shell micelles were created self- assembly in aqueous solution. Then Curcumin and Docetaxel were loaded by nano precipitation method which lead to creation of Curcumin-Docetaxel /loaded mPEG-PCL (Cu-Do/ mPEG-PCL). The Curcumin- Docetaxel /loaded mPEG-PCL were characterized invitro through H1NMR,FT-IR and GPC technique. Further characterization by DLS and AFM has been done. Result: H1NMR,FT-IR and GPC information confirm the successful formation of mPEG-PCL copolymer. AFM analysis showed the spherical shapes of CUDO/mPEG-PCL micelle with size of 52.6 nm. The encapsulation efficiency of CuDo is 48% with drug loading percentage of 15%. Invitro release of Cu-Do micelles strongly revealed the behavior of release which followed by zero order delivery profile. Conclusion: Data analysis results indicates the successful formation of Cudo/mPEG-PCL micelle. As a result, Cu-Do/mPEGPCL micelle is a appropriate and effective system for treatment of Atherosclerosis.